Despite a clear association between obesity, insulin resistance and atherosclerosis in
humans, to date, no animal models have been described in which insulin resistance is
associated with atherosclerotic lesion burden. Using two mouse models of obesity-induced
hyperlipidemia: leptin deficient (ob/ob) mice on an apolipoprotein E deficient (apoE−/−) or
low density lipoprotein receptor deficient (LDLR−/−) background, we sought to determine
metabolic parameters most closely associated with atherosclerotic lesion burden. Total …