Core-binding factors in haematopoiesis and leukaemia
NA Speck, DG Gilliland - Nature Reviews Cancer, 2002 - nature.com
NA Speck, DG Gilliland
Nature Reviews Cancer, 2002•nature.comCore-binding factors (CBFs) are a class of haematopoietic transcription factors that are
crucial for the regulation of haematopoietic ontogeny, and are frequent targets of mutation
and gene rearrangement in human leukaemia. So, what are the functions of CBFs during
development, and what are the functional consequences of CBF mutations in leukaemia?
Synergy between these convergent lines of enquiry has furthered our understanding of both
normal and malignant haematopoiesis.
crucial for the regulation of haematopoietic ontogeny, and are frequent targets of mutation
and gene rearrangement in human leukaemia. So, what are the functions of CBFs during
development, and what are the functional consequences of CBF mutations in leukaemia?
Synergy between these convergent lines of enquiry has furthered our understanding of both
normal and malignant haematopoiesis.
Abstract
Core-binding factors (CBFs) are a class of haematopoietic transcription factors that are crucial for the regulation of haematopoietic ontogeny, and are frequent targets of mutation and gene rearrangement in human leukaemia. So, what are the functions of CBFs during development, and what are the functional consequences of CBF mutations in leukaemia? Synergy between these convergent lines of enquiry has furthered our understanding of both normal and malignant haematopoiesis.
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