[HTML][HTML] Roles of Sca-1 in hematopoietic stem/progenitor cell function
SB Bradfute, TA Graubert, MA Goodell - Experimental hematology, 2005 - Elsevier
OBJECTIVE: This study was focused on studying the role of Sca-1 (Ly-6 A/E) in
hematopoietic stem/progenitor cell self-renewal, activation, and lineage fate. MATERIALS
AND METHODS: Sca-1−/− bone marrow cells were transplanted into wild-type recipient
mice and assessed for self-renewal activity and lineage choice. In addition, Sca-1−/− mice
were injected with 5-FU and Lin− cells were analyzed. Sca-1 was also overexpressed in
mouse and human stem/progenitor cells to assess the effect of Sca-1 overexpression on …
hematopoietic stem/progenitor cell self-renewal, activation, and lineage fate. MATERIALS
AND METHODS: Sca-1−/− bone marrow cells were transplanted into wild-type recipient
mice and assessed for self-renewal activity and lineage choice. In addition, Sca-1−/− mice
were injected with 5-FU and Lin− cells were analyzed. Sca-1 was also overexpressed in
mouse and human stem/progenitor cells to assess the effect of Sca-1 overexpression on …