[HTML][HTML] Membrane-bound stem cell factor is a key regulator in the initial lodgment of stem cells within the endosteal marrow region
RL Driessen, HM Johnston, SK Nilsson - Experimental hematology, 2003 - Elsevier
OBJECTIVE: The transmembrane isoform of stem cell factor (tm-SCF) has been implicated in
the adhesion of hemopoietic stem cells to the extracellular matrix within the bone marrow
microenvironment in vitro. In addition, in vivo SCF has been shown to play a role in cell
mobilization and migration. The aim of this study was to determine if SCF is an integral
component of the hemopoietic “niche” of the bone marrow in situ. MATERIALS AND
METHODS: To analyze the role of tm-SCF in cell lodgment, purified populations of primitive …
the adhesion of hemopoietic stem cells to the extracellular matrix within the bone marrow
microenvironment in vitro. In addition, in vivo SCF has been shown to play a role in cell
mobilization and migration. The aim of this study was to determine if SCF is an integral
component of the hemopoietic “niche” of the bone marrow in situ. MATERIALS AND
METHODS: To analyze the role of tm-SCF in cell lodgment, purified populations of primitive …