Continuation electroconvulsive therapy vs pharmacotherapy for relapse prevention in major depression: a multisite study from the Consortium for Research in …
CH Kellner, RG Knapp, G Petrides… - Archives of general …, 2006 - jamanetwork.com
Background Although electroconvulsive therapy (ECT) has been shown to be extremely
effective for the acute treatment of major depression, it has never been systematically
assessed as a strategy for relapse prevention. Objective To evaluate the comparative
efficacy of continuation ECT (C-ECT) and the combination of lithium carbonate plus
nortriptyline hydrochloride (C-Pharm) in the prevention of depressive relapse. Design
Multisite, randomized, parallel design, 6-month trial performed from 1997 to 2004. Setting …
effective for the acute treatment of major depression, it has never been systematically
assessed as a strategy for relapse prevention. Objective To evaluate the comparative
efficacy of continuation ECT (C-ECT) and the combination of lithium carbonate plus
nortriptyline hydrochloride (C-Pharm) in the prevention of depressive relapse. Design
Multisite, randomized, parallel design, 6-month trial performed from 1997 to 2004. Setting …