A susceptibility gene for affective disorders and the response of the human amygdala
AR Hariri, EM Drabant, KE Munoz… - Archives of general …, 2005 - jamanetwork.com
Background A common regulatory variant (5-HTTLPR) in the human serotonin transporter
gene (SLC6A4), resulting in altered transcription and transporter availability, has been
associated with vulnerability for affective disorders, including anxiety and depression. A
recent functional magnetic resonance imaging study suggested that this association may be
mediated by 5-HTTLPR effects on the response bias of the human amygdala—a brain
region critical for emotional and social behavior—to environmental threat. Objectives and …
gene (SLC6A4), resulting in altered transcription and transporter availability, has been
associated with vulnerability for affective disorders, including anxiety and depression. A
recent functional magnetic resonance imaging study suggested that this association may be
mediated by 5-HTTLPR effects on the response bias of the human amygdala—a brain
region critical for emotional and social behavior—to environmental threat. Objectives and …