Regional cerebral metabolism associated with anxiety symptoms in affective disorder patients

EA Osuch, TA Ketter, TA Kimbrell, MS George… - Biological …, 2000 - Elsevier
Background: We studied the relationship between regional cerebral metabolism and the
severity of anxiety in mood disorder patients, controlling for depression severity. Methods:
Fifty-two medication-free patients with unipolar or bipolar illness underwent positron
emission tomography with [18F]-fluorodeoxyglucose. Hamilton Depression Rating Scale
and Spielberger Anxiety-State Scale scores were obtained for the week of the scan.
Analyses were performed on globally normalized images and were corrected for multiple …