Autism spectrum disorders in Prader–Willi and Angelman syndromes: a systematic review
MWM Veltman, EE Craig, PF Bolton - Psychiatric genetics, 2005 - journals.lww.com
Autism spectrum disorders (ASDs) have been linked with maternally derived duplications/
triplications of chromosome 15q11–13 and therefore might occur more frequently in people
with Prader–Willi syndrome (PWS) when due to uniparental disomy (UPD), than in other
forms of chromosomal abnormality involving this region [ie deletion (DEL) forms of PWS and
DEL+ UPD forms of Angelman's syndrome–(AS)]. Twelve studies regarding ASD in PWS
and AS were reviewed. It was noteworthy that among the genetically confirmed UPD and …
triplications of chromosome 15q11–13 and therefore might occur more frequently in people
with Prader–Willi syndrome (PWS) when due to uniparental disomy (UPD), than in other
forms of chromosomal abnormality involving this region [ie deletion (DEL) forms of PWS and
DEL+ UPD forms of Angelman's syndrome–(AS)]. Twelve studies regarding ASD in PWS
and AS were reviewed. It was noteworthy that among the genetically confirmed UPD and …