Transplacental effects of 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin on the temporal modulation of Sp1 DNA binding in the developing cerebral cortex and cerebellum

T Nayyar, NH Zawia, DB Hood - Experimental and Toxicologic Pathology, 2002 - Elsevier
Gestational exposure to environmental pollutants such as 2, 3, 7, 8-tetrachlorodibenzo-p-
dioxin,(dioxin) often leads to neurodevelopmental and neurobehavioral deficits, which
clearly suggest the involvement of the central nervous system. The objective of this study
was to determine the effects of an acute, gestational exposure to dioxin on the
developmental expression profile of a transcription factor (Sp1) that is involved in growth
and differentiation in the developing brain of F1 generation pups. Timed-pregnant Harlan …