The broad autism phenotype: a complementary strategy for molecular genetic studies of autism

J Piven - American journal of medical genetics, 2001 - Wiley Online Library
J Piven
American journal of medical genetics, 2001Wiley Online Library
The genetic liability for autism appears to be expressed not only as the full syndrome of
autism, but in milder, qualitatively similar characteristics that collectively have been referred
to as constituting the broad autism phenotype. Identification of components of the broad
autism phenotype that segregate independently in relatives of autistic individuals may
provide an index of genes that, when present together, may interact to produce autism.
Inclusion of information on the broad autism phenotype in relatives, in linkage studies of …
Abstract
The genetic liability for autism appears to be expressed not only as the full syndrome of autism, but in milder, qualitatively similar characteristics that collectively have been referred to as constituting the broad autism phenotype. Identification of components of the broad autism phenotype that segregate independently in relatives of autistic individuals may provide an index of genes that, when present together, may interact to produce autism. Inclusion of information on the broad autism phenotype in relatives, in linkage studies of autism, may provide a potentially important, complementary approach for detecting the genes causing this condition. Am. J. Med. Genet. (Neuropsychiatr. Genet.) 105:34–35, 2001. © 2001 Wiley‐Liss, Inc.
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