PTEN and the PI3-kinase pathway in cancer
N Chalhoub, SJ Baker - Annual Review of Pathology …, 2009 - annualreviews.org
N Chalhoub, SJ Baker
Annual Review of Pathology: Mechanisms of Disease, 2009•annualreviews.orgPI3-kinase and PTEN are major positive and negative regulators, respectively, of the PI3-
kinase pathway, which regulates growth, survival, and proliferation. These key signaling
components are two of the most frequently mutated proteins in human cancers, resulting in
unregulated activation of PI3K signaling and providing irrefutable genetic evidence of the
central role of this pathway in tumorigenesis. PTEN regulates PI3K signaling by
dephosphorylating the lipid signaling intermediate PIP3, but PTEN may have additional …
kinase pathway, which regulates growth, survival, and proliferation. These key signaling
components are two of the most frequently mutated proteins in human cancers, resulting in
unregulated activation of PI3K signaling and providing irrefutable genetic evidence of the
central role of this pathway in tumorigenesis. PTEN regulates PI3K signaling by
dephosphorylating the lipid signaling intermediate PIP3, but PTEN may have additional …
PI3-kinase and PTEN are major positive and negative regulators, respectively, of the PI3-kinase pathway, which regulates growth, survival, and proliferation. These key signaling components are two of the most frequently mutated proteins in human cancers, resulting in unregulated activation of PI3K signaling and providing irrefutable genetic evidence of the central role of this pathway in tumorigenesis. PTEN regulates PI3K signaling by dephosphorylating the lipid signaling intermediate PIP3, but PTEN may have additional phosphatase-independent activities, as well as other functions in the nucleus. In this review, we highlight current work showing cancer-relevant complexities in the regulation of PTEN and PI3K activity, potential novel functions for PTEN, and feedback regulation within the pathway. The significance and complexity of PI3K signaling make it an important but challenging therapeutic target for cancer.
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