Preclinical models: status of basic research in depression

EJ Nestler, E Gould, H Manji - Biological psychiatry, 2002 - Elsevier
Approximately one half-century ago several classes of medications, discovered by
serendipity, were introduced for the treatment of depression and bipolar disorder. These
highly effective medications revolutionized our approach to mood disorders and helped
launch the modern era of psychiatry. Yet our progress since those serendipitous discoveries
has been disappointing. We still do not understand with certainty how those medications
produce their desired clinical effects. We have not introduced newer medications with …