Synaptic pathology in the anterior cingulate cortex in schizophrenia and mood disorders. A review and a Western blot study of synaptophysin, GAP-43 and the …

SL Eastwood, PJ Harrison - Brain research bulletin, 2001 - Elsevier
There are several reports of ultrastructural and protein changes affecting synapses in the
anterior cingulate cortex in schizophrenia. Altered cytoarchitecture has also been described
in this region in schizophrenia as well as in mood disorders. In this paper we review the
literature and present a new study investigating synaptic abnormalities in the anterior
cingulate cortex (area 24) in the Stanley Foundation brain series. We used Western blotting
to assess four synaptic proteins: synaptophysin, growth-associated protein-43 (GAP-43) …