Decreased N-acetylaspartate in children with familial bipolar disorder
BACKGROUND: Relatively low levels of brain N-acetylaspartate, as measured by magnetic
resonance spectroscopy, may indicate decreased neuronal density or viability. Dorsolateral
prefrontal levels of N-acetylaspartate have been reported to be decreased in adults with
bipolar disorder. We used proton magnetic resonance spectroscopy to investigate
dorsolateral prefrontal N-acetylaspartate levels in children with familial bipolar disorder.
METHODS: Subjects were 15 children and adolescents with bipolar disorder, who each had …
resonance spectroscopy, may indicate decreased neuronal density or viability. Dorsolateral
prefrontal levels of N-acetylaspartate have been reported to be decreased in adults with
bipolar disorder. We used proton magnetic resonance spectroscopy to investigate
dorsolateral prefrontal N-acetylaspartate levels in children with familial bipolar disorder.
METHODS: Subjects were 15 children and adolescents with bipolar disorder, who each had …