[PDF][PDF] Perisomatic inhibition

TF Freund, I Katona - Neuron, 2007 - cell.com
TF Freund, I Katona
Neuron, 2007cell.com
Recent evidence supports the hypothesis of a functional dichotomy of perisomatic inhibition
in the cerebral cortex: the parvalbumin-and cholecystokinin-containing basket cells that are
specialized to control rhythm (as a clockwork) and" mood"(as a fine-tuning device),
respectively, of network oscillations. Pathology extends this conclusion further, as the former
is implicated in epilepsy and the latter in anxiety. The well-balanced cooperation of the two
inhibitory systems is required for the normal network operations underlying the cognitive …
Recent evidence supports the hypothesis of a functional dichotomy of perisomatic inhibition in the cerebral cortex: the parvalbumin- and cholecystokinin-containing basket cells that are specialized to control rhythm (as a clockwork) and "mood" (as a fine-tuning device), respectively, of network oscillations. Pathology extends this conclusion further, as the former is implicated in epilepsy and the latter in anxiety. The well-balanced cooperation of the two inhibitory systems is required for the normal network operations underlying the cognitive functions of the cerebral cortex.
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