Moderation of the effect of adolescent-onset cannabis use on adult psychosis by a functional polymorphism in the catechol-O-methyltransferase gene: longitudinal …

A Caspi, TE Moffitt, M Cannon, J McClay, R Murray… - Biological …, 2005 - Elsevier
BACKGROUND: Recent evidence documents that cannabis use by young people is a
modest statistical risk factor for psychotic symptoms in adulthood, such as hallucinations and
delusions, as well as clinically significant schizophrenia. The vast majority of cannabis users
do not develop psychosis, however, prompting us to hypothesize that some people are
genetically vulnerable to the deleterious effects of cannabis. METHODS: In a longitudinal
study of a representative birth cohort followed to adulthood, we tested why cannabis use is …