Ketamine-induced deficits in auditory and visual context-dependent processing in healthy volunteers: implications for models of cognitive deficits in schizophrenia
D Umbricht, L Schmid, R Koller… - Archives of general …, 2000 - jamanetwork.com
Background In patients with schizophrenia, deficient generation of mismatch negativity
(MMN)—an event-related potential (ERP) indexing auditory sensory (" echoic") memory—
and a selective increase of" context dependent"(" BX") errors in the" AX" version of the
Continuous Performance Test (AX-CPT) indicate an impaired ability to form and use
transient memory traces. Animal and human studies implicate deficientN-methyl-D-aspartate
receptor (NMDAR) functioning in such abnormalities. In this study, effects of the NMDAR …
(MMN)—an event-related potential (ERP) indexing auditory sensory (" echoic") memory—
and a selective increase of" context dependent"(" BX") errors in the" AX" version of the
Continuous Performance Test (AX-CPT) indicate an impaired ability to form and use
transient memory traces. Animal and human studies implicate deficientN-methyl-D-aspartate
receptor (NMDAR) functioning in such abnormalities. In this study, effects of the NMDAR …