Toward a neurodevelopmental model of obsessive–compulsive disorder
DR Rosenberg, MS Keshavan - Biological psychiatry, 1998 - Elsevier
Background: Neurobiological models for obsessive–compulsive disorder (OCD) have
consistently implicated ventral prefrontal cortical and striatal circuits in the pathophysiology
of this disorder, but typically have not utilized a developmental framework for
conceptualizing the illness. Methods: We describe an integrated series of neurobiologic
studies aimed at testing the hypothesis that neurodevelopmental abnormalities of ventral
prefrontal–striatal circuits may be involved in and contribute to the etiology and presentation …
consistently implicated ventral prefrontal cortical and striatal circuits in the pathophysiology
of this disorder, but typically have not utilized a developmental framework for
conceptualizing the illness. Methods: We describe an integrated series of neurobiologic
studies aimed at testing the hypothesis that neurodevelopmental abnormalities of ventral
prefrontal–striatal circuits may be involved in and contribute to the etiology and presentation …