[HTML][HTML] The PDZ domain protein PICK1 and the sodium channel BNaC1 interact and localize at mechanosensory terminals of dorsal root ganglion neurons and …

A Duggan, J Garcıa-Anoveros, DP Corey - Journal of Biological Chemistry, 2002 - ASBMB
Members of the BNaC/ASIC family of ion channels have been implicated in
mechanotransduction and nociception mediated by dorsal root ganglion (DRG) neurons.
These ion channels are also expressed in the CNS. We identified the PDZ domain protein
PICK1 as an interactor of BNaC1 (ASIC2) in a yeast two-hybrid screen. We show by two-
hybrid assays, glutathione S-transferase pull-down assays, and coimmunoprecipitations that
the BNaC1· PICK1 interaction is specific, and that coexpression of both proteins leads to …