Monospecific anti‐GD1b IgG is required to induce rabbit ataxic neuropathy
S Kusunoki, S Hitoshi, KI Kaida, M Arita… - Annals of Neurology …, 1999 - Wiley Online Library
S Kusunoki, S Hitoshi, KI Kaida, M Arita, I Kanazawa
Annals of Neurology: Official Journal of the American Neurological …, 1999•Wiley Online LibraryOf 22 rabbits sensitized with GD1b, 12 developed experimental sensory ataxic neuropathy.
The affected rabbits had a higher level of serum IgG monospecific to GD1b than the
unaffected ones. The GD1b‐positive neuronal cytoplasms of rabbit dorsal root ganglia had
larger diameters than the negative ones. IgG antibody monospecific to GD1b may
preferentially bind to large primary sensory neurons, causing sensory ataxic neuropathy.
Ann Neurol 1999; 45: 400–403
The affected rabbits had a higher level of serum IgG monospecific to GD1b than the
unaffected ones. The GD1b‐positive neuronal cytoplasms of rabbit dorsal root ganglia had
larger diameters than the negative ones. IgG antibody monospecific to GD1b may
preferentially bind to large primary sensory neurons, causing sensory ataxic neuropathy.
Ann Neurol 1999; 45: 400–403
Abstract
Of 22 rabbits sensitized with GD1b, 12 developed experimental sensory ataxic neuropathy. The affected rabbits had a higher level of serum IgG monospecific to GD1b than the unaffected ones. The GD1b‐positive neuronal cytoplasms of rabbit dorsal root ganglia had larger diameters than the negative ones. IgG antibody monospecific to GD1b may preferentially bind to large primary sensory neurons, causing sensory ataxic neuropathy. Ann Neurol 1999;45:400–403
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