Cell membrane changes in brains manifesting senile plaques: an immunohistochemical study of GM1 membranous ganglioside
N Iwamoto, Y Suzuki, Y Makino, C Haga, K Kosaka… - Brain Research, 1990 - Elsevier
N Iwamoto, Y Suzuki, Y Makino, C Haga, K Kosaka, R Iizuka
Brain Research, 1990•ElsevierTo investigate structural changes in cell membranes of the Alzheimer-type dementia (ATD)
brain, we immunostained for GM 1 ganglioside which is a major component of the cell
membrane. Our results have shown that astrocytic membranes and senile plaques (SPs)
have the same immunoreactivity against the monoclonal anti-ganglioside GM 1 antibody.
Moreover, the astrocytic processes within the SPs were altered and their abnormal
membranes seemed to contribute to the formation of SPs.
brain, we immunostained for GM 1 ganglioside which is a major component of the cell
membrane. Our results have shown that astrocytic membranes and senile plaques (SPs)
have the same immunoreactivity against the monoclonal anti-ganglioside GM 1 antibody.
Moreover, the astrocytic processes within the SPs were altered and their abnormal
membranes seemed to contribute to the formation of SPs.
Abstract
To investigate structural changes in cell membranes of the Alzheimer-type dementia (ATD) brain, we immunostained for GM1 ganglioside which is a major component of the cell membrane. Our results have shown that astrocytic membranes and senile plaques (SPs) have the same immunoreactivity against the monoclonal anti-ganglioside GM1 antibody. Moreover, the astrocytic processes within the SPs were altered and their abnormal membranes seemed to contribute to the formation of SPs.
Elsevier