[HTML][HTML] Transgenic and recombinant resistin impair skeletal muscle glucose metabolism in the spontaneously hypertensive rat
M Pravenec, L Kazdová, V Landa, V Zídek… - Journal of Biological …, 2003 - ASBMB
Increased serum levels of resistin, a molecule secreted by fat cells, have been proposed as
a possible mechanistic link between obesity and insulin resistance. To further investigate the
effects of resistin on glucose metabolism, we derived a novel transgenic strain of
spontaneously hypertensive rats expressing the mouse resistin gene under the control of the
fat-specific aP2 promoter and also performed in vitro studies of the effects of recombinant
resistin on glucose metabolism in isolated skeletal muscle. Expression of the resistin …
a possible mechanistic link between obesity and insulin resistance. To further investigate the
effects of resistin on glucose metabolism, we derived a novel transgenic strain of
spontaneously hypertensive rats expressing the mouse resistin gene under the control of the
fat-specific aP2 promoter and also performed in vitro studies of the effects of recombinant
resistin on glucose metabolism in isolated skeletal muscle. Expression of the resistin …