Etiology of insulin resistance

KF Petersen, GI Shulman - The American journal of medicine, 2006 - Elsevier
Type 2 diabetes mellitus is a major cause of morbidity and mortality worldwide, and the
prevalence is set to increase dramatically over the coming decades. Understanding the
metabolic pathways that lead to type 2 diabetes is therefore an important healthcare
objective. Novel investigational techniques based on magnetic resonance spectroscopy
(MRS) have allowed real-time insight into the molecular defects in patients with type 2
diabetes, revealing that insulin resistance is a product of decreased insulin-stimulated …