Resistin gene expression in human adipocytes is not related to insulin resistance
J Janke, S Engeli, K Gorzelniak, FC Luft… - Obesity …, 2002 - Wiley Online Library
J Janke, S Engeli, K Gorzelniak, FC Luft, AM Sharma
Obesity research, 2002•Wiley Online LibraryObjectives: Obesity is an important risk factor for the development of insulin resistance and
type 2 diabetes. Recently, a newly described circulating hormone resistin, which is
expressed primarily in adipocytes, has been shown to antagonize insulin action in mice.
Resistin, therefore, has been suggested to play a role in the pathogenesis of insulin
resistance. Research Methods and Procedures: We studied the expression of the resistin
gene in primary cultured human adipocytes and preadipocytes. We also examined resistin …
type 2 diabetes. Recently, a newly described circulating hormone resistin, which is
expressed primarily in adipocytes, has been shown to antagonize insulin action in mice.
Resistin, therefore, has been suggested to play a role in the pathogenesis of insulin
resistance. Research Methods and Procedures: We studied the expression of the resistin
gene in primary cultured human adipocytes and preadipocytes. We also examined resistin …
Abstract
Objectives: Obesity is an important risk factor for the development of insulin resistance and type 2 diabetes. Recently, a newly described circulating hormone resistin, which is expressed primarily in adipocytes, has been shown to antagonize insulin action in mice. Resistin, therefore, has been suggested to play a role in the pathogenesis of insulin resistance.
Research Methods and Procedures: We studied the expression of the resistin gene in primary cultured human adipocytes and preadipocytes. We also examined resistin gene expression in subcutaneous abdominal adipocytes in women (n = 24) over a wide range of body weight and insulin sensitivity.
Results: Whereas resistin gene expression was barely detectable in mature adipocytes, it was highly expressed in preadipocytes. Adipogenic differentiation of preadipocytes was associated with a time‐dependent down‐regulation of resistin gene expression. There was no relationship between body weight, insulin sensitivity, or other metabolic parameters and adipocyte resistin gene expression in the clinical study.
Discussion: Together these findings do not support an important role of adipose‐tissue resistin gene expression in human insulin resistance.
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