[HTML][HTML] Reversible glutathionylation of complex I increases mitochondrial superoxide formation

ER Taylor, F Hurrell, RJ Shannon, TK Lin, J Hirst… - Journal of Biological …, 2003 - ASBMB
Increased production of reactive oxygen species (ROS) by mitochondria is involved in
oxidative damage to the organelle and in committing cells to apoptosis or senescence, but
the mechanisms of this increase are unknown. Here we show that ROS production by
mitochondrial complex I increases in response to oxidation of the mitochondrial glutathione
pool. This correlates with thiols on the 51-and 75-kDa subunits of complex I forming mixed
disulfides with glutathione. Glutathionylation of complex I increases superoxide production …