Disruption of mitochondrial redox circuitry in oxidative stress

DP Jones - Chemico-biological interactions, 2006 - Elsevier
The present review and commentary considers oxidative stress as a disruption of
mitochondrial redox circuitry rather than an imbalance of oxidants and antioxidants.
Mitochondria contain two types of redox circuits, high-flux pathways that are central to
mechanisms for ATP production and low-flux pathways that utilize sulfur switches of proteins
for metabolic regulation and cell signaling. The superoxide anion radical (hereafter termed
“superoxide”, O2−), a well known free radical product of the high-flux mitochondrial electron …