[HTML][HTML] Inflammation, stress, and diabetes

KE Wellen, GS Hotamisligil - The Journal of clinical …, 2005 - Am Soc Clin Investig
The Journal of clinical investigation, 2005Am Soc Clin Investig
Over the last decade, an abundance of evidence has emerged demonstrating a close link
between metabolism and immunity. It is now clear that obesity is associated with a state of
chronic low-level inflammation. In this article, we discuss the molecular and cellular
underpinnings of obesity-induced inflammation and the signaling pathways at the
intersection of metabolism and inflammation that contribute to diabetes. We also consider
mechanisms through which the inflammatory response may be initiated and discuss the …
Over the last decade, an abundance of evidence has emerged demonstrating a close link between metabolism and immunity. It is now clear that obesity is associated with a state of chronic low-level inflammation. In this article, we discuss the molecular and cellular underpinnings of obesity-induced inflammation and the signaling pathways at the intersection of metabolism and inflammation that contribute to diabetes. We also consider mechanisms through which the inflammatory response may be initiated and discuss the reasons for the inflammatory response in obesity. We put forth for consideration some hypotheses regarding important unanswered questions in the field and suggest a model for the integration of inflammatory and metabolic pathways in metabolic disease.
The Journal of Clinical Investigation