Characteristics of platelet aggregation induced by the monoclonal antibody ALB6 (acute lymphoblastic leukemia antigen p 24): inhibition of aggregation by ALB6Fab
C Boucheix, C Soria, M Mirshahi, J Soria, JY Perrot… - FEBS letters, 1983 - Elsevier
C Boucheix, C Soria, M Mirshahi, J Soria, JY Perrot, N Fournier, M Billard, C Rosenfeld
FEBS letters, 1983•ElsevierThe leukemia-associated cell surface antigen p 24 is found on normal platelets as well as on
Bernard Soulier syndrome and thrombasthenia type I platelets. ALB 6 IgG (a monoclonal
antibody against p 24) induces the aggregation of platelets from normal donors but not from
thrombasthenia. In contrast, ALB 6 Fab inhibits platelet aggregation induced by collagen,
ADP, thrombin, ionophore A 23187 and ALB 6 IgG. The results suggest that ALB 6 interferes
with a mechanism common to all aggregation pathways; the possible mechanisms are …
Bernard Soulier syndrome and thrombasthenia type I platelets. ALB 6 IgG (a monoclonal
antibody against p 24) induces the aggregation of platelets from normal donors but not from
thrombasthenia. In contrast, ALB 6 Fab inhibits platelet aggregation induced by collagen,
ADP, thrombin, ionophore A 23187 and ALB 6 IgG. The results suggest that ALB 6 interferes
with a mechanism common to all aggregation pathways; the possible mechanisms are …
Abstract
The leukemia-associated cell surface antigen p 24 is found on normal platelets as well as on Bernard Soulier syndrome and thrombasthenia type I platelets. ALB6 IgG (a monoclonal antibody against p 24) induces the aggregation of platelets from normal donors but not from thrombasthenia. In contrast, ALB6 Fab inhibits platelet aggregation induced by collagen, ADP, thrombin, ionophore A 23187 and ALB6 IgG. The results suggest that ALB6 interferes with a mechanism common to all aggregation pathways; the possible mechanisms are discussed.
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