[HTML][HTML] Phosphatidylinositol 3, 4, 5-trisphosphate-dependent stimulation of phospholipase C-γ2 is an early key event in FcγRIIA-mediated activation of human …
MP Gratacap, B Payrastre, C Viala, G Mauco… - Journal of Biological …, 1998 - ASBMB
Platelets express a single class of Fcγ receptor (FcγRIIA), which is involved in heparin-
associated thrombocytopenia and possibly in inflammation. FcγRIIA cross-linking induces
platelet secretion and aggregation, together with a number of cellular events such as
tyrosine phosphorylation, activation of phospholipase C-γ2 (PLC-γ2), and calcium signaling.
Here, we show that in response to FcγRIIA cross-linking, phosphatidylinositol (3, 4, 5)-
trisphosphate (PtdIns (3, 4, 5) P 3) is rapidly produced, whereas phosphatidylinositol (3, 4) …
associated thrombocytopenia and possibly in inflammation. FcγRIIA cross-linking induces
platelet secretion and aggregation, together with a number of cellular events such as
tyrosine phosphorylation, activation of phospholipase C-γ2 (PLC-γ2), and calcium signaling.
Here, we show that in response to FcγRIIA cross-linking, phosphatidylinositol (3, 4, 5)-
trisphosphate (PtdIns (3, 4, 5) P 3) is rapidly produced, whereas phosphatidylinositol (3, 4) …