[HTML][HTML] The tyrosine phosphatase 1B regulates linker for activation of T-cell phosphorylation and platelet aggregation upon FcγRIIA cross-linking
A Ragab, S Bodin, C Viala, H Chap, B Payrastre… - Journal of Biological …, 2003 - ASBMB
Human platelets express the receptor for immunoglobulin G, FcγRIIa, that triggers cell
aggregation upon interaction with immune complexes. Here, we report that the rapid
tyrosine phosphorylation of the Linker for Activation of T-cell (LAT) in human platelets
stimulated by FcγRIIa cross-linking was followed by its complete dephosphorylation in an
αIIb/β3 integrin-dependent manner. Concomitant to LAT dephosphorylation, the protein
tyrosine phosphatase 1B (PTP1B) was activated through a mechanism involving its …
aggregation upon interaction with immune complexes. Here, we report that the rapid
tyrosine phosphorylation of the Linker for Activation of T-cell (LAT) in human platelets
stimulated by FcγRIIa cross-linking was followed by its complete dephosphorylation in an
αIIb/β3 integrin-dependent manner. Concomitant to LAT dephosphorylation, the protein
tyrosine phosphatase 1B (PTP1B) was activated through a mechanism involving its …