The retardation of aging in mice by dietary restriction: longevity, cancer, immunity and lifetime energy intake
R Weindruch, RL Walford, S Fligiel, D Guthrie - The Journal of nutrition, 1986 - Elsevier
We sought to clarify the impact of dietary restriction (undernutrition without malnutrition) on
aging. Female mice from a long-lived strain were fed after weaning in one of six ways: group
1) a nonpurified diet and libitum; 2) 85 kcal/wk of a purified diet (∼ 25% restriction); 3) 50
kcal/wk of a restricted purified diet enriched in protein, vitamin and mineral content to
provide nearly equal intakes of these essentials as in group 2 (∼ 55% restriction); 4) as per
group 3, but also restricted before weaning; 5) 50 kcal/wk of a vitamin-and mineral-enriched …
aging. Female mice from a long-lived strain were fed after weaning in one of six ways: group
1) a nonpurified diet and libitum; 2) 85 kcal/wk of a purified diet (∼ 25% restriction); 3) 50
kcal/wk of a restricted purified diet enriched in protein, vitamin and mineral content to
provide nearly equal intakes of these essentials as in group 2 (∼ 55% restriction); 4) as per
group 3, but also restricted before weaning; 5) 50 kcal/wk of a vitamin-and mineral-enriched …