The biochemistry of sirtuins

AA Sauve, C Wolberger, VL Schramm… - Annu. Rev …, 2006 - annualreviews.org
AA Sauve, C Wolberger, VL Schramm, JD Boeke
Annu. Rev. Biochem., 2006annualreviews.org
Sirtuins are a family of NAD+-dependent protein deacetylases widely distributed in all phyla
of life. Accumulating evidence indicates that sirtuins are important regulators of organism life
span. In yeast, these unique enzymes regulate gene silencing by histone deacetylation and
via formation of the novel compound 2′-O-acetyl-ADP-ribose. In multicellular organisms,
sirtuins deacetylate histones and transcription factors that regulate stress, metabolism, and
survival pathways. The chemical mechanism of sirtuins provides novel opportunities for …
Abstract
Sirtuins are a family of NAD+-dependent protein deacetylases widely distributed in all phyla of life. Accumulating evidence indicates that sirtuins are important regulators of organism life span. In yeast, these unique enzymes regulate gene silencing by histone deacetylation and via formation of the novel compound 2′-O-acetyl-ADP-ribose. In multicellular organisms, sirtuins deacetylate histones and transcription factors that regulate stress, metabolism, and survival pathways. The chemical mechanism of sirtuins provides novel opportunities for signaling and metabolic regulation of protein deacetylation. The biological, chemical, and structural characteristics of these unusual enzymes are discussed in this review.
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