[HTML][HTML] PARP goes transcription
PARP-1, an enzyme that catalyzes the attachment of ADP ribose units to target proteins,
plays at least two important roles in transcription regulation. First, PARP-1 modifies histones
and creates an anionic poly (ADPribose) matrix that binds histones, thereby promoting the
decondensation of higher-order chromatin structures. Second, PARP-1 acts as a component
of enhancer/promoter regulatory complexes. Recent studies have shown that both of these
activities are critical for gene regulation in vivo.
plays at least two important roles in transcription regulation. First, PARP-1 modifies histones
and creates an anionic poly (ADPribose) matrix that binds histones, thereby promoting the
decondensation of higher-order chromatin structures. Second, PARP-1 acts as a component
of enhancer/promoter regulatory complexes. Recent studies have shown that both of these
activities are critical for gene regulation in vivo.
Abstract
PARP-1, an enzyme that catalyzes the attachment of ADP ribose units to target proteins, plays at least two important roles in transcription regulation. First, PARP-1 modifies histones and creates an anionic poly(ADPribose) matrix that binds histones, thereby promoting the decondensation of higher-order chromatin structures. Second, PARP-1 acts as a component of enhancer/promoter regulatory complexes. Recent studies have shown that both of these activities are critical for gene regulation in vivo.
cell.com