Functional analysis of a homopolymeric (dA-dT) element that provides nucleosomal access to yeast and mammalian transcription factors
KA Koch, DJ Thiele - Journal of Biological Chemistry, 1999 - ASBMB
Eukaryotic organisms ranging from yeast to humans maintain a large amount of genetic
information in the highly compact folds of chromatin, which poses a large DNA accessibility
barrier to rapid changes in gene expression. The ability of the yeast Candida glabrata to
survive copper insult requires rapid transcriptional autoactivation of the AMT1 copper-
metalloregulatory transcription factor gene. The kinetics of AMT1 autoactivation is greatly
enhanced by homopolymeric (dA-dT) element (A16)-mediated nucleosomal accessibility for …
information in the highly compact folds of chromatin, which poses a large DNA accessibility
barrier to rapid changes in gene expression. The ability of the yeast Candida glabrata to
survive copper insult requires rapid transcriptional autoactivation of the AMT1 copper-
metalloregulatory transcription factor gene. The kinetics of AMT1 autoactivation is greatly
enhanced by homopolymeric (dA-dT) element (A16)-mediated nucleosomal accessibility for …
