[HTML][HTML] The upstream regulatory regions of the hepatocyte growth factor gene promoter are essential for its expression in transgenic mice
AW Bell, JG Jiang, Q Chen, Y Liu, R Zarnegar - Journal of Biological …, 1998 - ASBMB
To understand the molecular mechanisms of hepatocyte growth factor (HGF) gene
transcription in vivo, we report the generation and characterization of transgenic mice
harboring various lengths of the mouse HGF promoter linked to the chloramphenicol
acetyltransferase reporter gene. Analysis of different tissues of the transgenic mouse lines
having the 2.7-kilobase (kb) promoter construct revealed a pattern of reporter gene
expression in embryonic and adult tissues that paralleled that of endogenous HGF gene …
transcription in vivo, we report the generation and characterization of transgenic mice
harboring various lengths of the mouse HGF promoter linked to the chloramphenicol
acetyltransferase reporter gene. Analysis of different tissues of the transgenic mouse lines
having the 2.7-kilobase (kb) promoter construct revealed a pattern of reporter gene
expression in embryonic and adult tissues that paralleled that of endogenous HGF gene …