[HTML][HTML] Wnt-3A/β-catenin signaling induces transcription from the LEF-1 promoter* 210
M Filali, N Cheng, D Abbott, V Leontiev… - Journal of Biological …, 2002 - ASBMB
Members of the Wnt family of secreted molecules have been established as key factors in
determining cell fate and morphogenic signaling. It has long been recognized that Wnt
induces morphogenic signaling through the Tcf/LEF-1 cascade by regulating free
intracellular levels of β-catenin, a co-factor for Tcf/LEF-1 transcription factors. In the present
study, we have demonstrated that Wnt-3A can also directly induce transcription from theLEF-
1 promoter. This induction was dependent on glycogen synthase kinase 3β inactivation, a …
determining cell fate and morphogenic signaling. It has long been recognized that Wnt
induces morphogenic signaling through the Tcf/LEF-1 cascade by regulating free
intracellular levels of β-catenin, a co-factor for Tcf/LEF-1 transcription factors. In the present
study, we have demonstrated that Wnt-3A can also directly induce transcription from theLEF-
1 promoter. This induction was dependent on glycogen synthase kinase 3β inactivation, a …