PI3K-FRAP/mTOR pathway is critical for hepatocyte proliferation whereas MEK/ERK supports both proliferation and survival
A Coutant, C Rescan, D Gilot, P Loyer… - Hepatology, 2002 - Elsevier
Growth factors are known to favor both proliferation and survival of hepatocytes. In this work,
we investigated the role of 2 main signaling pathways, phosphoinositide 3-kinase (PI3K)
and mitogen-activated protein kinase (MEK)/extracellular signal–regulated kinase (ERK), in
these processes. First, evidence was provided that the PI3K cascade as well as the
MEK/ERK cascade is a key transduction pathway controlling hepatocyte proliferation, as
ascertained by arrest of DNA synthesis in the presence of LY294002, a specific PI3K …
we investigated the role of 2 main signaling pathways, phosphoinositide 3-kinase (PI3K)
and mitogen-activated protein kinase (MEK)/extracellular signal–regulated kinase (ERK), in
these processes. First, evidence was provided that the PI3K cascade as well as the
MEK/ERK cascade is a key transduction pathway controlling hepatocyte proliferation, as
ascertained by arrest of DNA synthesis in the presence of LY294002, a specific PI3K …