A randomized, placebo-controlled, clinical trial of high-dose supplementation with vitamins C and E, beta carotene, and zinc for age-related macular degeneration and …

Age-Related Eye Disease Study … - Archives of …, 2001 - jamanetwork.com
Background Observational and experimental data suggest that antioxidant and/or zinc
supplements may delay progression of age-related macular degeneration (AMD) and vision
loss. Objective To evaluate the effect of high-dose vitamins C and E, beta carotene, and zinc
supplements on AMD progression and visual acuity. Design The Age-Related Eye Disease
Study, an 11-center double-masked clinical trial, enrolled participants in an AMD trial if they
had extensive small drusen, intermediate drusen, large drusen, noncentral geographic …