[HTML][HTML] The role of NHERF and E3KARP in the cAMP-mediated inhibition of NHE3

G Lamprecht, EJ Weinman, CHC Yun - Journal of Biological Chemistry, 1998 - ASBMB
NHE3 is the apically located Na+/H+ exchanger in the gut and in the renal proximal tubule.
Acute inhibition of this transporter by cAMP requires the presence of either of two NHE3-
associated proteins, NHERF or E3KARP. It has been suggested that these proteins either
directly regulate NHE3 activity after being phosphorylated by protein kinase A (PKA) or that
they may serve as adapters that localize PKA near NHE3. We studied the role of NHERF
and E3KARP in opossum kidney cells, which endogenously express NHE3, NHERF, and …