[HTML][HTML] Stress management: MHC class I and class I-like molecules as reporters of cellular stress
M Gleimer, P Parham - Immunity, 2003 - cell.com
M Gleimer, P Parham
Immunity, 2003•cell.comThe evolutionarily ancient intracellular stress response protects cells from the effects of
external and internal forces which perturb cellular metabolism. Members of the major
histocompatibility complex (MHC) class I-like superfamily act as cell surface indicators of the
intracellular stress response. Cellular immunity employs these indicators as a cue for
elimination of damaged, infected, and malignant cells, promoting the health of the individual
and the evolutionary success of the species.
external and internal forces which perturb cellular metabolism. Members of the major
histocompatibility complex (MHC) class I-like superfamily act as cell surface indicators of the
intracellular stress response. Cellular immunity employs these indicators as a cue for
elimination of damaged, infected, and malignant cells, promoting the health of the individual
and the evolutionary success of the species.
Abstract
The evolutionarily ancient intracellular stress response protects cells from the effects of external and internal forces which perturb cellular metabolism. Members of the major histocompatibility complex (MHC) class I-like superfamily act as cell surface indicators of the intracellular stress response. Cellular immunity employs these indicators as a cue for elimination of damaged, infected, and malignant cells, promoting the health of the individual and the evolutionary success of the species.
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