CD8+ T cells contribute to macrophage accumulation and airspace enlargement following repeated irritant exposure
MT Borchers, SC Wesselkamper, NL Harris… - … and molecular pathology, 2007 - Elsevier
BACKGROUND: Persistent macrophage accumulation and alveolar enlargement are
hallmark features of chronic obstructive pulmonary disease (COPD). A role for CD8+
lymphocytes in the development of COPD is suggested based on observations that this T
cell subset is increased in the airways and parenchyma of smokers that develop COPD with
airflow limitation. In this study, we utilize a mouse model of COPD to examine the
contributions of CD8+ T cells in the persistent macrophage accumulation and airspace …
hallmark features of chronic obstructive pulmonary disease (COPD). A role for CD8+
lymphocytes in the development of COPD is suggested based on observations that this T
cell subset is increased in the airways and parenchyma of smokers that develop COPD with
airflow limitation. In this study, we utilize a mouse model of COPD to examine the
contributions of CD8+ T cells in the persistent macrophage accumulation and airspace …