Glycyrrhetinic acid derivatives: a novel class of inhibitors of gap-junctional intercellular communication. Structure-activity relationships.
JS Davidson, IM Baumgarten - Journal of Pharmacology and Experimental …, 1988 - ASPET
JS Davidson, IM Baumgarten
Journal of Pharmacology and Experimental Therapeutics, 1988•ASPETGlycyrrhetinic acid was shown previously to inhibit intercellular gap-junctional
communication between human fibroblasts. In the present study 31 derivatives of
glycyrrhetinic acid were tested for their ability to inhibit communication. Eight of the
compounds inhibited communication with high potency (IC50 less than 3 microM) and
showed low toxicity, properties which suggest they may be useful pharmacological probes
for studies of gap-junction function.
communication between human fibroblasts. In the present study 31 derivatives of
glycyrrhetinic acid were tested for their ability to inhibit communication. Eight of the
compounds inhibited communication with high potency (IC50 less than 3 microM) and
showed low toxicity, properties which suggest they may be useful pharmacological probes
for studies of gap-junction function.
Glycyrrhetinic acid was shown previously to inhibit intercellular gap-junctional communication between human fibroblasts. In the present study 31 derivatives of glycyrrhetinic acid were tested for their ability to inhibit communication. Eight of the compounds inhibited communication with high potency (IC50 less than 3 microM) and showed low toxicity, properties which suggest they may be useful pharmacological probes for studies of gap-junction function.
ASPET