Impaired cerebral cortical gray matter growth after treatment with dexamethasone for neonatal chronic lung disease

BP Murphy, TE Inder, PS Huppi, S Warfield… - …, 2001 - publications.aap.org
Objective. The specific aim of this study was to quantify at term the influence of postnatal
systemic dexamethasone treatment for neonatal chronic lung disease on subsequent brain
growth and development in premature infants without evidence of severe intraventricular
hemorrhage or white matter injury. Methods. Eighteen premature (23 to 31 weeks) infants, 7
treated with dexamethasone and 11 not treated, were studied at term, ie, 38 to 41
postconceptional weeks, by an advanced quantitative volumetric 3-dimensional magnetic …