Transcriptional control of COX-2 via C/EBPβ

KK Wu, JY Liou, K Cieslik - Arteriosclerosis, thrombosis, and …, 2005 - Am Heart Assoc
KK Wu, JY Liou, K Cieslik
Arteriosclerosis, thrombosis, and vascular biology, 2005Am Heart Assoc
Cyclooxygenase-2 (COX-2) is a highly inducible enzyme exerting diverse actions on cell
functions, including proliferation, migration, and DNA damage. Enhanced COX-2 expression
may be protective, but excessive expression may be harmful, causing inflammation,
atheromatous plaque instability, and intimal hyperplasia. COX-2 transcriptional activation by
proinflammatory mediators has been extensively characterized. In this review, the role of
C/EBP in regulating COX-2 transcription is highlighted. Recent advances in control of COX-2 …
Cyclooxygenase-2 (COX-2) is a highly inducible enzyme exerting diverse actions on cell functions, including proliferation, migration, and DNA damage. Enhanced COX-2 expression may be protective, but excessive expression may be harmful, causing inflammation, atheromatous plaque instability, and intimal hyperplasia. COX-2 transcriptional activation by proinflammatory mediators has been extensively characterized. In this review, the role of C/EBP in regulating COX-2 transcription is highlighted. Recent advances in control of COX-2 transcription by aspirin and salicylate and by a cell cycle-dependent endogenous mechanism are described. The recent progress sheds light on the pathophysiological mechanisms of COX-2 and new transcription-based strategy for controlling COX-2 overexpression and COX-2–mediated cardiovascular diseases.
Am Heart Assoc