Toll-like receptor 9 (TLR9) is present in murine liver sinusoidal endothelial cells (LSECs) and mediates the effect of CpG-oligonucleotides
M Martin-Armas, J Simon-Santamaria, I Pettersen… - Journal of …, 2006 - Elsevier
BACKGROUND/AIMS: Bacterial DNA and synthetic oligonucleotides containing
unmethylated motifs have become the focus of many studies due to their ability to activate
cells of the innate immune system through interaction with Toll-like receptor 9 (TLR9). This
study was undertaken to investigate if and how CpG-oligonucleotides (CpGs) activate liver
sinusoidal endothelial cells (LSECs), known to be the main site of clearance of DNA-
oligonucleotides from the circulation. METHODS: Expression of TLR9 was analyzed by RT …
unmethylated motifs have become the focus of many studies due to their ability to activate
cells of the innate immune system through interaction with Toll-like receptor 9 (TLR9). This
study was undertaken to investigate if and how CpG-oligonucleotides (CpGs) activate liver
sinusoidal endothelial cells (LSECs), known to be the main site of clearance of DNA-
oligonucleotides from the circulation. METHODS: Expression of TLR9 was analyzed by RT …