[HTML][HTML] Non-oncogene addiction and the stress phenotype of cancer cells
NL Solimini, J Luo, SJ Elledge - Cell, 2007 - cell.com
NL Solimini, J Luo, SJ Elledge
Cell, 2007•cell.comHeat-shock factor 1 (HSF1) is a transcription factor that is activated upon proteotoxic stress
and coordinates induction of the heat-shock response. In this issue, Dai et al.(2007) show
that HSF1 is a potent modifier of tumorigenesis and is required for tumor initiation and
maintenance in a variety of cancer models. These findings add HSF1 to a growing list of non-
oncogenes that could be exploited as cancer drug targets.
and coordinates induction of the heat-shock response. In this issue, Dai et al.(2007) show
that HSF1 is a potent modifier of tumorigenesis and is required for tumor initiation and
maintenance in a variety of cancer models. These findings add HSF1 to a growing list of non-
oncogenes that could be exploited as cancer drug targets.
Heat-shock factor 1 (HSF1) is a transcription factor that is activated upon proteotoxic stress and coordinates induction of the heat-shock response. In this issue, Dai et al. (2007) show that HSF1 is a potent modifier of tumorigenesis and is required for tumor initiation and maintenance in a variety of cancer models. These findings add HSF1 to a growing list of non-oncogenes that could be exploited as cancer drug targets.
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