Spinal synthesis and release of prostanoids after peripheral injury and inflammation
DM Dirig, TL Yaksh - Eicosanoids and Other Bioactive Lipids in Cancer …, 1999 - Springer
DM Dirig, TL Yaksh
Eicosanoids and Other Bioactive Lipids in Cancer, Inflammation, and Radiation …, 1999•SpringerAfter peripheral injury and inflammation, the close relationship between stimulus intensity
and response to acute injurious stimuli is altered. Peripheral injury and inflammation
increase a subject's responsiveness to noxious stimuli (ie pain reports, paw withdrawal
latency, or electrophysiological recordings) relative to the un-injured state (Raja et al., 1988).
This hypersensitivity can be expressed as a decreased response latency to a noxious
stimulus (hyperalgesia) or a nocifensive response (ie pain report or escape attempts) to an …
and response to acute injurious stimuli is altered. Peripheral injury and inflammation
increase a subject's responsiveness to noxious stimuli (ie pain reports, paw withdrawal
latency, or electrophysiological recordings) relative to the un-injured state (Raja et al., 1988).
This hypersensitivity can be expressed as a decreased response latency to a noxious
stimulus (hyperalgesia) or a nocifensive response (ie pain report or escape attempts) to an …
Abstract
After peripheral injury and inflammation, the close relationship between stimulus intensity and response to acute injurious stimuli is altered. Peripheral injury and inflammation increase a subject’s responsiveness to noxious stimuli (i.e. pain reports, paw withdrawal latency, or electrophysiological recordings) relative to the un-injured state (Raja et al., 1988). This hypersensitivity can be expressed as a decreased response latency to a noxious stimulus (hyperalgesia) or a nocifensive response (i.e. pain report or escape attempts) to an innocuous stimulus (allodynia). These altered stimulus-response relationships may result from peripheral as well as central mechanisms; this review will focus on spinal prostanoid synthesis and hyperalgesia after peripheral injury and inflammation.
Springer