Heme oxygenase type 2 participates in the development of chronic inflammatory and neuropathic pain
X Li, JD Clark - The journal of pain, 2003 - Elsevier
Heme oxygenase (HO) catalyzes the conversion of heme to biliverdin, iron, and carbon
monoxide. Recent studies have demonstrated that inhibitors of HO are analgesic in a
number of different pain models. In these studies we attempted to define the role of HO type
2 (HO-2) in the development of chronic inflammatory and neuropathic pain. To do this both
wild type and C57Bl/6 HO-2 null mutant mice were either injected with complete Freund
[apos] s adjuvant in 1 hind paw or underwent unilateral partial sciatic nerve ligation. The …
monoxide. Recent studies have demonstrated that inhibitors of HO are analgesic in a
number of different pain models. In these studies we attempted to define the role of HO type
2 (HO-2) in the development of chronic inflammatory and neuropathic pain. To do this both
wild type and C57Bl/6 HO-2 null mutant mice were either injected with complete Freund
[apos] s adjuvant in 1 hind paw or underwent unilateral partial sciatic nerve ligation. The …