Leptin is a link between adipose tissue and inflammation

P Härle, RH Straub - Annals of the New York Academy of …, 2006 - Wiley Online Library
P Härle, RH Straub
Annals of the New York Academy of Sciences, 2006Wiley Online Library
Leptin is a hormone of the pluripotent white adipose tissue and confers a multitude of
regulatory functions within the organism. It controls the energy storage, lipoprotein
metabolism, acute phase reactants, sex hormones and glucocorticoid metabolism, and
immune function. In this review, we describe these multiple functions of leptin, the regulation
of leptin expression, and how leptin can modulate the immune system via direct and indirect
mechanisms. We show how leptin can be a link between the adipose tissue and …
Abstract
Leptin is a hormone of the pluripotent white adipose tissue and confers a multitude of regulatory functions within the organism. It controls the energy storage, lipoprotein metabolism, acute phase reactants, sex hormones and glucocorticoid metabolism, and immune function. In this review, we describe these multiple functions of leptin, the regulation of leptin expression, and how leptin can modulate the immune system via direct and indirect mechanisms. We show how leptin can be a link between the adipose tissue and inflammation.
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