Inflammation and hyperalgesia induced by nerve injury in the rat: a key role of mast cells
Y Zuo, NM Perkins, DJ Tracey, CL Geczy - Pain, 2003 - Elsevier
Inflammatory cells and their mediators are known to contribute to neuropathic pain following
nerve injury. Mast cells play a key role in non-neural models of inflammation and we
propose that mast cells and their mediators (in particular histamine) are important in the
development of neuropathic pain. In rats, where the sciatic nerve was partially ligated, we
showed that stabilisation of mast cells with sodium cromoglycate reduced the recruitment of
neutrophils and monocytes to the injured nerve and suppressed the development of …
nerve injury. Mast cells play a key role in non-neural models of inflammation and we
propose that mast cells and their mediators (in particular histamine) are important in the
development of neuropathic pain. In rats, where the sciatic nerve was partially ligated, we
showed that stabilisation of mast cells with sodium cromoglycate reduced the recruitment of
neutrophils and monocytes to the injured nerve and suppressed the development of …